Noradrenaline effects on oxidative metabolism (tricarboxylic acid cycle activity) were examined by measuring the formation of14CO2from labeled aspartate in primary cultures of cerebral astrocytes and neurons and of cerebellar granule cells. At all time periods studied, CO2formation in astrocytes was significantly increased in the presence of noradrenaline. The EC50value was calculated to be 5 × 10-7M. No corresponding stimulation of CO2production in cerebellar or cortical neurons was observed, suggesting that the stimulation of energy metabolism by noradrenaline in vivo may be confined to astrocytes. © 1990.
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