Models have been derived to predict process time and permeate volume for the purification of a macromolecule by ultrafiltration (in the concentration mode) or by continuous diafiltration. It requires only knowledge of the parameters of the film theory (gel-polarization) model for flux. Purification by discontinuous diafiltration usually results in less time and generates lower permeate volume than continuous diafiltration alone. The optimum appears to be a combined process where the feed is first pre-concentrated by ultrafiltration, followed by continuous diafiltration. © 1992.
Asbi, B. A., & Cheryan, M. (1992). Optimizing process time for utrafiltration and diafiltration. Desalination, 86(1), 49–62. https://doi.org/10.1016/0011-9164(92)80023-3