Oxygen regulates brain angiogenesis and tight junction formation in blood–brain barrier

  • Lee S
N/ACitations
Citations of this article
6Readers
Mendeley users who have this article in their library.
Get full text

Abstract

The maintenance of the blood–brain barrier (BBB) is important in the central nervous system because disruption of the BBB may contribute to many brain disorders, including Alzheimer's disease and stroke. However, the molecular mechanism of brain vessel development and BBB formation remains ill-defined. We found that the immunoreactivities of pimonidazol, hypoxic marker and vascular endothelial growth factor (VEGF) were detected in developing brain, and then disappeared after birth. However, the expression of occludin was gradually increased during BBB maturation. Moreover, we found src-suppressed C-kinase substrate (SSeCKS)-overexpressed in astrocytes during reoxygenation. Overexpressed SSeCKS strongly reduced the VEGF expression and angiogenesis. Furthermore, SSeCKS overexpression increased the expression of both angiopoietin-1 (Ang-1), an antipermeability factor, and tight junction proteins, consequently decreased [ 3 H]sucrose permeability. We therefore conclude that reoxygenation of astrocytes may act as a significant driving force for the BBB maturation, and SSeCKS is a novel regulator of BBB differentiation by modulating both brain angiogenesis and tight junction formation. © 2004, Elsevier Inc. All rights reserved.

Cite

CITATION STYLE

APA

Lee, S. (2004). Oxygen regulates brain angiogenesis and tight junction formation in blood–brain barrier. International Congress Series, 1262, 287–291. https://doi.org/10.1016/j.ics.2003.11.044

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free