Pancreatic polypeptide immunoreactivity in medullary carcinoma of the thyroid: identification and characterisation by radioimmunoassay, immunocytochemistry and high performance liquid chromatography

  • O'Hare M
  • Shaw C
  • Johnston C
 et al. 
  • 3


    Mendeley users who have this article in their library.
  • 8


    Citations of this article.


Pancreatic polypeptide immunoreactivity has been identified in primary medullary carcinoma of thyroid using radioimmunoassay and immunocytochemistry and subsequently characterised by HPLC. Two region-specific PP antisera were used in the study; one C-terminal and one non-C-terminal. These antisera demonstrate variable cross-reactivity with the molecular species of PP identified in the tumours. The immunoreactive material in the tumours corresponded to human PP and not PYY or NPY on the basis of immunoreactivity and HPLC behaviour. It was identified in all patients with familial-type disease but not in the two sporadic cases examined. We propose that estimation of the PP content of medullary carcinoma of thyroid may be a useful means of differentiating familial and sporadic types. © 1986.

Author-supplied keywords

  • HPLC
  • immunocytochemistry
  • medullary carcinoma of thyroid
  • multiple endocrine neoplasia (MEN) type II
  • pancreatic polypeptide

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • M. M.T. O'Hare

  • C. Shaw

  • C. F. Johnston

  • C. F.J. Russell

  • J. M. Sloan

  • K. D. Buchanan

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free