Pathology of hepatic peroxisomes in chronic hepatitis B and immunosuppression

  • Reinke P
  • David H
  • Uerlings I
 et al. 
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Abstract

After kidney transplantation and immunosuppressive therapy patients with chronic hepatitis B show not only peroxisome proliferation in hepatocytes but also additional alterations of these organelles: lysis and occasional complete loss of peroxisomes in HBsAg areas as well as lysis and/ or autophagocytic degradation of peroxisomes in hepatocytes which contained hepatitis-B virus particles. Two mechanisms are suggested as being significant for the numerical decrease of peroxisomes in HBsAg areas: Reduced neogenesis, but typical lytic degradation; Direct toxic action of immunosuppressive substances. For elucidation further studies have to be undertaken. © 1988, VEB Gustav Fischer Verlag Jena. All rights reserved.

Author-supplied keywords

  • HbcAg
  • HbsAg
  • NANB
  • hepatic peroxisomes
  • hepatitis B
  • hepatitis B core antigen
  • hepatitis B surface antigen
  • hepatocyte
  • immunosuppression
  • kidney transplantation
  • liver
  • non-A non-B hepatitis

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Authors

  • P. Reinke

  • H. David

  • I. Uerlings

  • Th Decker

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