Pathology of hepatic peroxisomes in chronic hepatitis B and immunosuppression

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After kidney transplantation and immunosuppressive therapy patients with chronic hepatitis B show not only peroxisome proliferation in hepatocytes but also additional alterations of these organelles: lysis and occasional complete loss of peroxisomes in HBsAg areas as well as lysis and/ or autophagocytic degradation of peroxisomes in hepatocytes which contained hepatitis-B virus particles. Two mechanisms are suggested as being significant for the numerical decrease of peroxisomes in HBsAg areas: Reduced neogenesis, but typical lytic degradation; Direct toxic action of immunosuppressive substances. For elucidation further studies have to be undertaken. © 1988, VEB Gustav Fischer Verlag Jena. All rights reserved.




Reinke, P., David, H., Uerlings, I., & Decker, T. (1988). Pathology of hepatic peroxisomes in chronic hepatitis B and immunosuppression. Experimental Pathology, 34(2), 71–77.

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