Pearls and Pitfalls in Evidence Based Medicine: What We've Learned About Outcomes Research in Spine Surgery

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Abstract

Spine care has become increasingly evidence-based. The investigators who have generated this evidence have learned important lessons that should help guide future trials: 1. Patients will agree to enroll in studies and to be randomized; 2. Patients will crossover between treatment arms if it is an option; 3. Observational studies can provide the best answers to some questions; 4. High quality clinical research is extremely expensive and work-intensive; 5. High quality spine research is needed now more than ever. This paper reviews these issues as they have arisen in recent clinical studies. © 2009 Elsevier Inc. All rights reserved.

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Pearson, A. M., & Weinstein, J. N. (2009). Pearls and Pitfalls in Evidence Based Medicine: What We’ve Learned About Outcomes Research in Spine Surgery. Seminars in Spine Surgery, 21(4), 264–267. https://doi.org/10.1053/j.semss.2009.08.010

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