Pearls and Pitfalls in Evidence Based Medicine: What We've Learned About Outcomes Research in Spine Surgery

  • Pearson A
  • Weinstein J
  • 4


    Mendeley users who have this article in their library.
  • 0


    Citations of this article.


Spine care has become increasingly evidence-based. The investigators who have generated this evidence have learned important lessons that should help guide future trials: 1. Patients will agree to enroll in studies and to be randomized; 2. Patients will crossover between treatment arms if it is an option; 3. Observational studies can provide the best answers to some questions; 4. High quality clinical research is extremely expensive and work-intensive; 5. High quality spine research is needed now more than ever. This paper reviews these issues as they have arisen in recent clinical studies. © 2009 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • clinical trials
  • crossover
  • spine surgery

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Adam M. Pearson

  • James N. Weinstein

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free