Persistence of small fragments of newly synthesized DNA in bacteria following thymidine starvation

  • Freifelder D
  • Katz G
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Thymine starvation of Escherichia coli results in the accumulation of Okazaki fragments. This is interpreted to mean that DNA ligase is inhibited in a thyminestarved cell. However phage λ covalent circles still form in such a starved cell. It is suggested that this is because only a very low level of ligase activity is necessary for this conversion. © 1971.

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  • David Freifelder

  • Gerson Katz

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