Thymine starvation of Escherichia coli results in the accumulation of Okazaki fragments. This is interpreted to mean that DNA ligase is inhibited in a thyminestarved cell. However phage λ covalent circles still form in such a starved cell. It is suggested that this is because only a very low level of ligase activity is necessary for this conversion. © 1971.
Freifelder, D., & Katz, G. (1971). Persistence of small fragments of newly synthesized DNA in bacteria following thymidine starvation. Journal of Molecular Biology, 57(2), 351–354. https://doi.org/10.1016/0022-2836(71)90351-2