Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen

  • Hoehn K
  • Reid A
  • Sawynok J
  • 5


    Mendeley users who have this article in their library.
  • 71


    Citations of this article.


The effect of intrathecal pretreatment with pertussis toxin on the spinal antinociceptive effect of morphine, noradrenaline and L-baclofen was examined in rats implanted with chronic indwelling cannulas. Pretreatment with 0.25-0.75 μg pertussis toxin for 2-7 days inhibited antinociception produced by intrathecal injection of all three agents in the tail flick test. Inhibition also occurred in the hot plate test, butwas less pronounced than in the tail flick test. When doses of the three agents giving similar levels of antinociception were compared in a single group, the degree of inhibition of antinociception was comparable. Inhibition of the effect of noradrenaline was observed up to 14 days following pretreatment. The sensitivity of spinal antinociception to pertussis toxin suggests involvement of a guanine nucleotide regulatory protein in spinal actions of morphine, noradrenaline and L-baclofen. There is support in the literature for the additional involvement of adenylate cyclase in the action of morphine and noradrenaline but not of baclofen. © 1988.

Author-supplied keywords

  • Baclofen
  • Morphine
  • Noradrenaline
  • Pertussis toxin
  • Tail flick test

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Katja Hoehn

  • Allison Reid

  • Jana Sawynok

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free