pH-dependent modulation of agonist interactions with [3H]-ketanserin-labelled S2serotonin receptors

  • Battaglia G
  • Shannon M
  • Borgundvaag B
 et al. 
  • 2


    Mendeley users who have this article in their library.
  • 20


    Citations of this article.


The effects of varying the pH on the properties of S2serotonin receptors labelled by [3H]-ketanserin were examined. Between pH 7.0 and 8.2 the agonist affinities, as determined by competition experiments, increased dramatically. Serotonin, 5-methoxytryptamine, tryptamine, bufotenine and quipazine, demonstrated 15,16,8,6 and 5-fold increases in apparent affinity between pH 7.0 and 8.2. On the other hand the antagonists, ketanserin, cinanserin, and spiperone demonstrated little or no affinity changes between pH 7.0 and 8.2. The largest shift in affinity for an antagonist occurred with spiperone, which displayed a two-fold shift. Although changing pH is a rather non-specific manipulation, the selective affect on agonist interaction with S2receptors indicates further investigation of this pH effect may aid in discovering the difference in receptor interactions between serotonin agonists and antagonists. © 1983.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • G. Battaglia

  • M. Shannon

  • B. Borgundvaag

  • M. Titeler

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free