Phenethylamine hallucinogens in the locus coeruleus: potency of action correlates with rank order of 5-HT2binding affinity

  • Rasmussen K
  • Glennon R
  • Aghajanian G
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Abstract

The rank order of potency for the physiological effects of three phenethylamine hallucinogens in the locus coeruleus (LC) was identical to that previously shown for their 5-HT2binding affinity ((-) DOB > DOM > (+)DOB). The behaviorally inactive positional isomer of DOB, SL-7161, did not significantly affect LC unit activity. These results offer insight into structure-activity relationships at 5-HT2receptors and support earlier findings that the actions of hallucinogens displayed in the LC are mediated via 5-HT2receptors. © 1986.

Author-supplied keywords

  • 5-HT2receptors
  • DOB
  • DOM
  • Hallucinogens
  • Locus coeruleus
  • SL-7161

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Authors

  • Kurt Rasmussen

  • Richard A. Glennon

  • George K. Aghajanian

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