Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells

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Abstract

3,5-Disubstituted-phenylcyanoguanidines have been identified as activators of SUR1/Kir6.2 potassium channels and as potent inhibitors of insulin release from pancreatic beta cells in vitro. © 2001 Elsevier Science Ltd.

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Tagmose, T. M., Mogensen, J. P., Agerholm, P. C., Arkhammar, P. O. G., Wahl, P., Worsaae, A., & Hansen, J. B. (2001). Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells. Bioorganic and Medicinal Chemistry Letters, 11(13), 1749–1752. https://doi.org/10.1016/S0960-894X(01)00297-9

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