Positive influence of AT1 receptor antagonism upon the impaired celiprolol-induced vasodilatation in aorta from spontaneously hypertensive rats

  • Sauvaget F
  • Mallem M
  • Bucas V
 et al. 
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Abstract

We evaluated celiprolol-induced vasodilatation in aorta taken from 12-week-old spontaneously hypertensive rats (SHR) and the effect of AT1angiotensin II receptor antagonism on the vasodilatory action of celiprolol in Wistar Kyoto (WKY) rats and SHR. In WKY rats, the celiprolol-induced relaxation was greatly decreased in denuded aorta, and completely abolished in intact aorta by Nω-nitro-l-arginine methyl ester (l-NAME, 100μM). In SHR, celiprolol-induced relaxation was reduced compared to WKY rats (Emax(value obtained for the highest concentration, 300μM)=39.1±3.78%, n=21 vs. 80.4±3% in WKY rats, n=10; P

Author-supplied keywords

  • (Rat)
  • Aorta
  • Celiprolol
  • SHR
  • Vasodilatation
  • β-Adrenergic receptor

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