The kinetic properties of voltage-gated Na+currents in two groups of glandular postganglionic sympathetic neurons were assessed. The first group of neurons remained innervated by preganglionic axons until the day of current recordings, while the second - decentralized 4 weeks prior to recordings. An increase of maximum current amplitude and density was noted in decentralized neurons. Na+currents activated and time-dependently inactivated more slowly in decentralized than in control neurons. Furthermore, after decentralization the currents steady-state inactivated at less hyperpolarized potentials as well as reactivated faster from inactivation. We conclude that the Na+currents in decentralized postganglionic glandular sympathetic neurons undergo up-regulation. © 2003 Elsevier Science Ireland Ltd. All rights reserved.
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