Powerful respiratory stimulation by thin muscle afferents

  • Yu J
  • Younes M
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The ventilatory responses to electrical stimulation of phrenic afferents were examined in spontaneously breathing dogs at different levels of sodium pentobarbital anesthesia. High intensity stimulation (activation of all the afferents, including thin fibers) increased ventilation (VE). The increase in VE was comparable to that of breathing 10% CO2and was inversely related to anesthesia level. Under light anesthesia, VE increased to 282±36% of the control value when the phrenic nerve was stimulated at 130 times the twitch threshold (n=15; P

Author-supplied keywords

  • Afferent fibers, phrenic, respiratory stimulation
  • Anesthesia level, phrenic afferent stimulation
  • Control of breathing, phrenic afferent activity
  • Mammals, dog

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  • J. Yu

  • M. Younes

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