Forty patients undergoing elective thoracotomy were studied to assess the possibility of predicting PaO2during one-lung ventilation (OLV) when continuous positive airway pressure (CPAP) was applied to the nondependent lung. The first 20 patients were studied retrospectively and the three most significant independent variables that correlated with PaO2during OLV with CPAP were: side of operation (P = 0.04), FEV1/FVC ratio (P = 0.01), and the intraoperative PaO2during two-lung ventilation (P = 0.0002). By the method of multiple linear regression, these three variables were used to construct a predictive equation for PaO2during OLV with CPAP. The second 20 patients were studied prospectively and the predicted PaO2correlated significantly with the observed PaO2during OLV with CPAP (r = 0.86, P < 0.001). Therefore, it is concluded that the PaO2during OLV with CPAP can be predicted using routinely available data. © 1990.
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