Preparative separation of polar unstable compounds (catecholamines) from a synthetic mixture by high-speed counter-current chromatography

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Abstract

When a test mixt. of norepinephrine [51-41-2] and dopamine [51-61-6]<br />was subjected to high-speed counter-current chromatog. on a multilayered<br />coil planet centrifuge, 2 major peaks (fractions 62-81 and 90-120)<br />were well resolved and eluted within 2 h. In test runs, 97% of norepinephrine<br />and 90% of dopamine applied to counter-current chromatog. were recovered<br />in combined fractions, as detd. by HPLC with electrochem. detection.<br />Thus, rapid and complete sepn. of the 2 catecholamines from a crude<br />mixt. shows that the high-speed counter-current chromatog. technique<br />has a great potential for use. [on SciFinder(R)]

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Weisz, A., Markey, S. P., & Ito, Y. (1986). Preparative separation of polar unstable compounds (catecholamines) from a synthetic mixture by high-speed counter-current chromatography. Journal of Chromatography B: Biomedical Sciences and Applications, 383(C), 132–136. https://doi.org/10.1016/S0378-4347(00)83450-7

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