Presence of the di-leucine motif in the cytoplasmic tail of the pig FcRn α chain

  • Zhao Y
  • Kacskovics I
  • Zhao Z
 et al. 
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Abstract

The sequence of the pig FcRn α chain was recently published. The lack of a conserved di-leucine motif in the cytoplasmic tail suggests a rare polymorphism in the described animal, alternatively, a sequencing error. We therefore cloned and sequenced the pig FcRn α chain. Our sequence, along with a previous NCBI GenBank submission and five pig derived EST clones clearly demonstrate the presence of di-leucine motif in the cytoplasmic tail of the pig FcRn. No polymorphism in the cytoplasmic tail-encoding region was found in 25 animals from six pig breeds based on single-stranded conformation polymorphism and sequencing analysis, suggesting that the previously described pig FcRn α chain may represent a sequencing error in the 3′ portion of the gene. © 2003 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Cytoplasmic tail
  • FcRn
  • Pig

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Authors

  • Yaofeng Zhao

  • Imre Kacskovics

  • Zhihui Zhao

  • Lennart Hammarström

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