Promutagen activation in partially hepatectomized mice

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Abstract

Mutagenic activity of aflatoxin B1(AFB1) was followed in the Ames Salmonella/microsome test using liver S-9 from control and partially hepatectomized (PH) mice. The S-9 preparations from the PH mice were capable of inducing significantly greater AFB1mutagenic activity to strain TA100 than S-9 preparations from either unoperated control, sham-operated control, or Aroclor 1254-induced mice. Increased activity was observed with S-9 preparations made at both 42 h and 148 h following PH. © 1982.

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Vandewaa, E. A., Barney, C. C., & Gentile, J. M. (1982). Promutagen activation in partially hepatectomized mice. Toxicology Letters, 14(3–4), 253–260. https://doi.org/10.1016/0378-4274(82)90060-1

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