Promutagen activation in partially hepatectomized mice

  • Vandewaa E
  • Barney C
  • Gentile J
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Abstract

Mutagenic activity of aflatoxin B1(AFB1) was followed in the Ames Salmonella/microsome test using liver S-9 from control and partially hepatectomized (PH) mice. The S-9 preparations from the PH mice were capable of inducing significantly greater AFB1mutagenic activity to strain TA100 than S-9 preparations from either unoperated control, sham-operated control, or Aroclor 1254-induced mice. Increased activity was observed with S-9 preparations made at both 42 h and 148 h following PH. © 1982.

Author-supplied keywords

  • Aflatoxin B1
  • Salmonella
  • enhancement
  • metabolism

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Authors

  • Elizabeth A. Vandewaa

  • Christopher C. Barney

  • James M. Gentile

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