Protective efficacy of mouse serum to the N-propionyl derivative of meningococcal group B polysaccharide

33Citations
Citations of this article
4Readers
Mendeley users who have this article in their library.
Get full text

Abstract

The protective properties of antibodies induced by immunization of mice with a conjugate of tetanus toxoid and the N-propionyl derivative of group B meningococcal polysaccharide (N-Pr-GBMP-TT) have been investigated. Mice immunized with the conjugate produced antibodies which were bactericidal for Neisseria meningitidis strains B:2b:P1.Ham and B:15:P1.16. Passive protection studies indicated that the conjugate serum completely eliminated or reduced considerably levels of bacteremia by the same strains in mice. There was no bactericidal activity or passive protection against a strain of N. meningitidis C:2b:P1.2. Following absorption of the conjugate serum with GBMP the non-absorbed antibody, directed to N-Pr-GBMP, was bactericidal and protected mice against bacteremia with group B meningococci. Thus N-Pr-GBMP antibodies which do not bind to the GBMP are protective in vitro and in vivo. © 1989.

Cite

CITATION STYLE

APA

Ashton, F. E., Ryan, J. A., Michon, F., & Jennings, H. J. (1989). Protective efficacy of mouse serum to the N-propionyl derivative of meningococcal group B polysaccharide. Microbial Pathogenesis, 6(6), 455–458. https://doi.org/10.1016/0882-4010(89)90087-9

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free