Quantitation of serum apolipoprotein A-I, A-II, B, C-II, C-III and E in healthy Japanese by turbidimetric immunoassay: Reference values, and age- and sex-related differences

  • Noma A
  • Hata Y
  • Goto Y
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Abstract

Serum apolipoproteins (Apo) A-I, A-II, B, C-II, C-III and E were determined in healthy Japanese subjects (male 1,603, female 1,800, aged 4-95 yr) by the turbidimetric immunoassay, with six kinds of automated instruments, and the commercial reagent kits with standards. There was a high degree of interlaboratory comparability of analytical values among the 15 participating laboratories. The reference values were calculated for adult males and females (male 677, female 467, aged 21-60 yr). Apo A-I and E levels were significantly higher and Apo C-II and C-III were significantly lower in females than in males. Furthermore, serum Apo A-I and A-II tended to decrease, and Apo B to increase with age. Apo C-II, C-III and E tended to decrease after 60 yr of age. © 1991.

Author-supplied keywords

  • Age- and sex-related differences
  • Apolipoprotein
  • Japanese subjects
  • Reference values
  • Turbidimetric immunoassay

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Authors

  • Akio Noma

  • Yoshiya Hata

  • Yuichiro Goto

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