A quick look at slow saccades after cardiac surgery: where is the lesion?

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Abstract

Saccadic palsy is a reported complication of cardiac surgery. One case that came to autopsy showed midline pontine gliosis; however, in most cases, no lesions are evident on neuroimaging. Since the saccadic palsy may range from single large slow saccades to a "staircase" of very small saccades that are normal in speed, it seems plausible that more than one mechanism is possible. Here we postulate that, in those patients who make a staircase of small saccades, loss of cerebellar Purkinje cells could cause fastigial nucleus neurons to fire prematurely, thereby decelerating saccades via inhibitory burst neurons. © 2008 Elsevier B.V. All rights reserved.

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Solomon, D., Ramat, S., Leigh, R. J., & Zee, D. (2008). A quick look at slow saccades after cardiac surgery: where is the lesion? Progress in Brain Research. https://doi.org/10.1016/S0079-6123(08)00685-7

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