The reaction of propiolate acetylides with nitrones. Synthesis of γ-amino-α,β-ethylenic acid derivatives

  • Denis J
  • Tchertchian S
  • Tomassini A
 et al. 
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Abstract

Nitrones react with the lithium anions of ethyl and t-butyl propiolates to give acetylenic N-hydroxylamines. The reduction of these compounds with Zn in the presence of an acid leads to E and Z α,β-ethylenic-γ-aminoacids derivatives. The stereoselectivity of these reactions was studied.

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Authors

  • Jean Noël Denis

  • Sylvie Tchertchian

  • Axel Tomassini

  • Yannick Vallée

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