The reactivities of carboxyl groups to carbodiimides in non-reduced, S-carboxymethyl, and S-cyanoethyl proteins have been compared. When disulphide bonds are split, a decrease in reactivity was found, relatively minor in the S-carboxymethyl derivative and almost complete loss of reactivities in the S-cyanoethyl derivative. © 1971.
Frater, R. (1971). Reactivity of carboxyl groups in modified proteins. FEBS Letters, 12(4), 186–188. https://doi.org/10.1016/0014-5793(71)80016-9