Region E3 of human adenoviruses; differences between the oncogenic adenovirus-3 and the non-oncogenic adenovirus-2

43Citations
Citations of this article
3Readers
Mendeley users who have this article in their library.
Get full text

Abstract

The nucleotide sequence of a 4379-bp-long DNA segment, located between map coordinates 76.5 and 89.2 in the Ad3 genome, was established. The segment includes the entire early transcription unit 3 (E3) and the 3′-part of the gene for the late polypeptide pVIII. The established sequence was compared to the sequence of the corresponding region in the Ad2 genome [Hérissé et al., Nucl. Acids Res. 8, (1980) 2173-2192; Hérissé and Galibert, Nucl. Acids Res. 9, (1981) 1229-1249]. Although Ad2 and Ad3 belong to different serological and oncogenic subgroups, their E3 regions are well conserved (55-60% homology). In total, the E3 region of Ad3 appears to encode eight to nine different polypeptides many of which are likely to be membrane-associated. The most conspicuous difference between the E3 regions of Ad2 and Ad3 is the presence of a 950-bp-long A + T-rich insert in the Ad3 sequence. This insert contains two open reading frames, each encoding a polypeptide with a predicted Mr of about 20 000. The mRNAs encoding these novel polypeptides were identified by S1 nuclease analysis. © 1986.

Cite

CITATION STYLE

APA

Signas, C., Akusjärvi, G., & Pettersson, U. (1986). Region E3 of human adenoviruses; differences between the oncogenic adenovirus-3 and the non-oncogenic adenovirus-2. Gene, 50(1–3), 173–184. https://doi.org/10.1016/0378-1119(86)90322-7

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free