Regulation of hemopexin transcription by calcium ionophores and phorbol ester in hepatoma cells

  • Stred S
  • Cote D
  • Weinstock R
 et al. 
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Abstract

Hemopexin (Hx) is an acute-phase hepatic protein, whose transcription is upregulated by IL-6. The transcription rate of Hx was found to be increased 11-fold by the calcium ionophore A23187, 25-fold by the calcium ionophore ionomycin, and 4-5-fold by phorbol 12-myristate 13-acetate (PMA) in serum-starved H4IIE rat hepatoma cells. Insulin did not affect the transcription rate of Hx. These findings are consistent with involvement of intracellular calcium concentrations and activation of protein kinase C (PKC) action in the regulation of Hx. © 2003 Elsevier Science Ireland Ltd. All rights reserved.

Author-supplied keywords

  • Acute phase protein
  • Calcium signaling
  • Gene expression
  • Growth hormone
  • Hemopexin
  • Hepatoma cells (rat)
  • Protein kinase C

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