Regulation of hemopexin transcription by calcium ionophores and phorbol ester in hepatoma cells

6Citations
Citations of this article
1Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Hemopexin (Hx) is an acute-phase hepatic protein, whose transcription is upregulated by IL-6. The transcription rate of Hx was found to be increased 11-fold by the calcium ionophore A23187, 25-fold by the calcium ionophore ionomycin, and 4-5-fold by phorbol 12-myristate 13-acetate (PMA) in serum-starved H4IIE rat hepatoma cells. Insulin did not affect the transcription rate of Hx. These findings are consistent with involvement of intracellular calcium concentrations and activation of protein kinase C (PKC) action in the regulation of Hx. © 2003 Elsevier Science Ireland Ltd. All rights reserved.

Cite

CITATION STYLE

APA

Stred, S. E., Cote, D., Weinstock, R. S., & Messina, J. L. (2003). Regulation of hemopexin transcription by calcium ionophores and phorbol ester in hepatoma cells. Molecular and Cellular Endocrinology, 204(1–2), 111–116. https://doi.org/10.1016/S0303-7207(03)00150-3

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free