Hemopexin (Hx) is an acute-phase hepatic protein, whose transcription is upregulated by IL-6. The transcription rate of Hx was found to be increased 11-fold by the calcium ionophore A23187, 25-fold by the calcium ionophore ionomycin, and 4-5-fold by phorbol 12-myristate 13-acetate (PMA) in serum-starved H4IIE rat hepatoma cells. Insulin did not affect the transcription rate of Hx. These findings are consistent with involvement of intracellular calcium concentrations and activation of protein kinase C (PKC) action in the regulation of Hx. © 2003 Elsevier Science Ireland Ltd. All rights reserved.
Stred, S. E., Cote, D., Weinstock, R. S., & Messina, J. L. (2003). Regulation of hemopexin transcription by calcium ionophores and phorbol ester in hepatoma cells. Molecular and Cellular Endocrinology, 204(1–2), 111–116. https://doi.org/10.1016/S0303-7207(03)00150-3