Reversal of the reserpine electroencephalographic synchronization in the rabbit by parachlorophenylalanine

  • Gaillard J
  • Herkert B
  • Tissot R
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Abstract

In the rabbit, reserpine induced an initial period of synchronization of the electroencephalogram which lasted about 30 min and was followed by a sustained pattern of electrical activation. Pretreatment with p-CPA reversed the initial reserpine synchronization, which was replaced by a continuous and very regular pattern of electrical activation. The sleep pattern following injection of reserpine is interpreted as related to a release of 5-HT in active sites and therefore available for synaptic transmission. This release of 5-HT predominates at the beginning of reserpine action and the subsequent activated period could be related to a dominance of catecholaminergic mechanisms. © 1974.

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Authors

  • J. M. Gaillard

  • B. Herkert

  • R. Tissot

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