In the rabbit, reserpine induced an initial period of synchronization of the electroencephalogram which lasted about 30 min and was followed by a sustained pattern of electrical activation. Pretreatment with p-CPA reversed the initial reserpine synchronization, which was replaced by a continuous and very regular pattern of electrical activation. The sleep pattern following injection of reserpine is interpreted as related to a release of 5-HT in active sites and therefore available for synaptic transmission. This release of 5-HT predominates at the beginning of reserpine action and the subsequent activated period could be related to a dominance of catecholaminergic mechanisms. © 1974.
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