In the rabbit, reserpine induced an initial period of synchronization of the electroencephalogram which lasted about 30 min and was followed by a sustained pattern of electrical activation. Pretreatment with p-CPA reversed the initial reserpine synchronization, which was replaced by a continuous and very regular pattern of electrical activation. The sleep pattern following injection of reserpine is interpreted as related to a release of 5-HT in active sites and therefore available for synaptic transmission. This release of 5-HT predominates at the beginning of reserpine action and the subsequent activated period could be related to a dominance of catecholaminergic mechanisms. © 1974.
Gaillard, J. M., Herkert, B., & Tissot, R. (1974). Reversal of the reserpine electroencephalographic synchronization in the rabbit by parachlorophenylalanine. Neuropharmacology, 13(8), 789–793. https://doi.org/10.1016/0028-3908(74)90026-4