Riboflavin protects mice against liposaccharide-induced shock through expression of heat shock protein 25

  • Shih C
  • Chen C
  • Chen C
 et al. 
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Abstract

Riboflavin (vitamin B2) is a water-soluble vitamin essential for normal cellular functions, growth and development. This study aimed to investigate the effects of vitamin B2 on the survival rate, and expressions of tissue heat shock protein 25 (HSP25) and heat shock factor 1 (HSF1) in mice undergoing lipopolysaccharide (LPS) induced shock. Mice were assigned to four groups, saline vehicle, LPS, LPS plus low dose of vitamin B2 (LB2) and LPS plus high dose of vitamin B2 (HB2). Vitamin B2 (1 and 10. mg/kg BW) was administered intraperitoneally at 2 and 0. h before the i.p. administration of LPS. At the end of the experiment, the survival rate monitored was 10, 20, 60, and 100% for LPS, LB2, HB2, and saline mice, respectively. HSP25 expressions in the heart and lung were significantly enhanced in a time-dependent manner in the HB2 mice as compared to the saline mice (p

Author-supplied keywords

  • Heat shock factor 1
  • Heat shock protein 25
  • Lipopolysaccharide
  • Sepsis
  • Vitamin B2

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Authors

  • Chun Kuang Shih

  • Chiao Ming Chen

  • C. Y Oliver Chen

  • Jen Fang Liu

  • Hui Wen Lin

  • Hung Tsung Chou

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