This chapter presents a clear account of antigen-specific T cell regulatory factors. The initial concept of interaction of thymus (T)-derived cells and bone marrow (B)-derived cells has been considerably broadened to incorporate macrophage–T cell, T cell–T cell, and T cell–B cell interactions, which as a whole constitute the network of an immunoregulatory system. The interconnectedness of the immunocompetent cells is discussed. The network concept explains it by idiotype–anti-idiotype interactions among lymphocytes. On the other hand, there is abundant experimental data indicating that cell interactions are governed by genes in the major histocompatibility complex (MHC). Several facets of antigen-specific T cell factors found independently by different investigators are examined. There exist both overt similarities and differences between these T bell factors with respect to their immunochemical properties, genetic control, and roles in the immune response. © 1979 Academic Press Inc.
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