The role of hexokinase as a possible modulator of Ca2+ movements in isolated rat brain mitochondria

  • Panfili E
  • Sandri G
  • 1


    Mendeley users who have this article in their library.
  • 11


    Citations of this article.


The present study shows that in brain mitochondria the active calcium uptake and the sodium-dependent calcium efflux are modulated by the porin-bound enzyme hexokinase. The release of the enzyme, promoted by glucose-6-phosphate (G-6-P), under conditions which do not affect mitochondrial functions, is accompanied by a decrease of the rates of fluxes of the cation. This phenomenon is discussed and correlated with the formation of microcompartments between the inner and outer mitochondrial membranes, where the hexokinase-porin complex may constitute a regulating gate system for calcium. © 1985.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Enrico Panfili

  • Gabriella Sandri

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free