Saccharides of senile plaques and neurofibrillary tangles in Alzheimer's disease

  • Mann D
  • Bonshek R
  • Marcyniuk B
 et al. 
  • 3


    Mendeley users who have this article in their library.
  • 17


    Citations of this article.


The contribution that oligosaccharides might make to the structure of the senile plaque and the neurofibrillary tangle was investigated using lectin histochemistry in 9 patients with Alzheimer's disease. One group of 4 lectins diffusely stained the neurites of senile plaques whereas two groups of 6 different lectins stained neurofibrillary tangles within neuronal perikarya and plaque neurites. Neuraminidase pretreatment abolished staining of tangles by one of these latter groups, but did not affect staining by the other group. Senile plaque core amyloid failed to stain with any lectin. It is concluded that oligosaccharides may contribute, but in different ways, to glycoprotein or glycolipid residues that form an integral part of the structure of the senile plaque and the neurofibrillary tangle. © 1988.

Author-supplied keywords

  • Alzheimer's disease
  • Lectin
  • Neurofibrillary tangle
  • Oligosaccharide
  • Senile plaque

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • D. M.A. Mann

  • R. E. Bonshek

  • B. Marcyniuk

  • R. W. Stoddart

  • E. Torgerson

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free