Sarafotoxin receptors mediate phosphoinositide hydrolysis in various rat brain regions

  • Kloog Y
  • Ambar I
  • Kochva E
 et al. 
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Abstract

Sarafotoxin-b, a potent snake vasoconstrictor peptide homologous to the mammalian endothelial vasoconstrictor endothelin, induces phosphoinositide (PI) hydrolysis in various brain regions of the rat. Sarafotoxin-b induced PI hydrolysis is largely independent of extracellular Ca2+and is detected in all brain regions where toxin-binding sites are found. These results point to the existence of a hitherto undetected neuroreceptor associated with the PI cycle. © 1989.

Author-supplied keywords

  • (Rat brain)
  • Endothelin
  • Phosphoinositide
  • Receptor
  • Sarafotoxin
  • Snake venom

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Authors

  • Y. Kloog

  • I. Ambar

  • E. Kochva

  • Z. Wollberg

  • A. Bdolah

  • M. Sokolovsky

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