Sarafotoxin-b, a potent snake vasoconstrictor peptide homologous to the mammalian endothelial vasoconstrictor endothelin, induces phosphoinositide (PI) hydrolysis in various brain regions of the rat. Sarafotoxin-b induced PI hydrolysis is largely independent of extracellular Ca2+and is detected in all brain regions where toxin-binding sites are found. These results point to the existence of a hitherto undetected neuroreceptor associated with the PI cycle. © 1989.
Kloog, Y., Ambar, I., Kochva, E., Wollberg, Z., Bdolah, A., & Sokolovsky, M. (1989). Sarafotoxin receptors mediate phosphoinositide hydrolysis in various rat brain regions. FEBS Letters, 242(2), 387–390. https://doi.org/10.1016/0014-5793(89)80507-1