Segmental amplification of 11q23 region identified by flourescence in situ hybridization in four patients with myeloid disorders: A review

19Citations
Citations of this article
3Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Four cases with a segmental amplification of 11q23 region were detected by FISH. The amplification was either contiguous amplification on chromosome 11, or multiple markers involving the 11q23 region. The markers were derivative chromosomes, or isochromosomes. Amplification of 11q23 region was associated with complex karyotypes at the time of diagnosis or following treatment in secondary leukemias. Three were AML cases belonging to either AML-M5a or AML-1 subtypes and one was a myeloproliferative disorder. These cases were resistant to treatment. Conventional cytogenetic analysis and fluorescence in situ hybridization (FISH) studies using MLL, 11 painting, or 11 centromere probes ascertained the segmental amplification. Since the patients did not respond to treatment the amplification of gene or genes that map to 11q23 may be responsible for the unfavorable prognosis. Hence, this type of amplifications could have clinical significance. © 2001 Elsevier Science Inc.

Cite

CITATION STYLE

APA

Reddy, K. S., Parsons, L., Mak, L., Dighe, P., Saphner, T., Crow, M. K., & Scott, M. (2001, April 15). Segmental amplification of 11q23 region identified by flourescence in situ hybridization in four patients with myeloid disorders: A review. Cancer Genetics and Cytogenetics. Elsevier Inc. https://doi.org/10.1016/S0165-4608(00)00406-4

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free