Seizure measurement in clinical trials

  • Cramer J
  • 2

    Readers

    Mendeley users who have this article in their library.
  • 5

    Citations

    Citations of this article.

Abstract

The traditional endpoint in clinical trials of antiepileptic drugs has been based on counting complex partial seizures. Other aspects of seizures such as severity and precipitating factors also should be considered. A review of scales developed to assess multiple aspects of seizures is used to define additional aspects of seizures that could be measured in clinical trials. Three scales (VA Seizures Frequency and Severity Scale, Liverpool Seizure Severity Scale, and National Hospital Seizure Severity Scale) are compared for 15 aspects of seizure assessment. Nontraditional methods of seizure assessment might provide valuable data that could differentiate among treatments.

Author-supplied keywords

  • Clinical trials
  • Clinimetric scale
  • Seizures

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Joyce A. Cramer

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free