Selective cleavage of skeletal myosin subfragment-1 to form a 26 kDa peptide which shows ATP-sensitive actin binding

  • Griffiths A
  • Trayer I
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Abstract

A 26 kDa peptide has been cleaved from the C-terminus of the S1 heavy chain with formic acid. Cleavage occurs in the '50 kDa' domain probably at the Asp-600-Pro-601 bond. This fragment has been renatured in the presence of the A2 light chain and the 26 kDa(A2) complex shown to interact with actin in an ATP-sensitive manner. © 1989.

Author-supplied keywords

  • ATP binding
  • Muscle contraction
  • Myosin
  • Protein fragmentation

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Authors

  • A. Jane Griffiths

  • Ian P. Trayer

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