Selective elevation of C-MYC transcript levels in the liver of the aging Fischer-344 rat

  • Matocha M
  • Cosgrove J
  • Atack J
 et al. 
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Abstract

The expression of several proto-oncogenes involved in normal cell growth was examined as a function of age in male Fischer-344 rats aged 3, 6-9, 12 and 21-23 months. Northern blot analysis using RNA isolated from pooled livers or brains showed that the transcript levels of c-myc, but not c-sis or c-src-related genes, were markedly elevated in the liver with age. In contrast, there was no substantial change in transcript levels of any of these genes in aging brain. When c-myc expression was analyzed in livers from individual rats ranging in age from 4 to 22 months, a significant (p

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Authors

  • Martha F. Matocha

  • James W. Cosgrove

  • John R. Atack

  • Stanley I. Rapoport

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