Sendai virus C protein impairs both phosphorylation and dephosphorylation processes of Stat1

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Abstract

Sendai virus expresses C protein that blocks interferon (IFN) signaling. We previously reported suppression of IFN-stimulated tyrosine phosphorylation of signal transducers and activators of transcription (Stats) in infected cells. However this conclusion has remained controversial. To settle it, we re-examined the effect of C protein expression on phosphorylation of Stat1 in detail. IFN-stimulated tyrosine phosphorylation of Stat1 was doubtlessly suppressed early in infection, but the suppression was incomplete, suggesting the importance of the unknown blocking mechanism that inactivates the tyrosine-phosphorylated (pY)-Stat1 generated as the signaling leak. Interestingly, the dephosphorylation process of pY-Stat1 was also impaired. These effects on both phosphorylation and dephosphorylation processes were attributable to the function of the C protein. © 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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Komatsu, T., Takeuchi, K., Yokoo, J., & Gotoh, B. (2002). Sendai virus C protein impairs both phosphorylation and dephosphorylation processes of Stat1. FEBS Letters, 511(1–3), 139–144. https://doi.org/10.1016/S0014-5793(01)03301-4

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