A short and efficient synthesis of 2′-deoxybenzo- and pyridoimidazole C-nucleosides

  • Jazouli M
  • Guianvarc'h D
  • Soufiaoui M
 et al. 
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Abstract

A short route to a series of 2′-deoxy-C-nucleosides featuring substituted nucleobases has been developed. The key step is the formation of the cyclized products following Mukaiyama's type amide coupling and a simple dehydration, starting from readily accessible synthons. The epimerization of the C1′-stereogenic center was avoided under mild and controlled conditions. © 2003 Elsevier Ltd. All rights reserved.

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Authors

  • Mohamed Jazouli

  • Dominique Guianvarc'h

  • Mohamed Soufiaoui

  • Pierre Vierling

  • Rachid Benhida

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