A simple method for synthesis of amides and peptides through acyl chlorides. A rapid synthesis of thyrotropin releasing hormone

  • Matsuda F
  • Itoh S
  • Hattori N
 et al. 
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Abstract

By improvement of the classical SOCl2-pyridine method for the preparation of acid chlorides, amides and optically pure peptides were synthesized rapidly in a simple manner from DCHA dicyclohexylammonium) salts of carboxylic acids. This modified SOCl2-pyridine method was applied to a rapid synthesis of TRH. © 1985.

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Authors

  • Fuyuhiko Matsuda

  • Shin Itoh

  • Noritaka Hattori

  • Mitsutoshi Yanagiya

  • Takeshi Matsumoto

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