The anti-Parkinson's agent SIB-1508Y was prepared in six steps from (S)-nicotine in 20% overall yield. The strategy involves a regioselective formylation at C-5 of a 1,4-dihydronicotine intermediate. © 2005 Elsevier Ltd. All rights reserved.
Comins, D. L., & Smith, E. D. (2006). A six-step synthesis of (S)-5-ethenyl-3-(1-methyl-2-pyrrolidinyl)pyridine (SIB-1508Y) from (S)-nicotine. Tetrahedron Letters, 47(9), 1449–1451. https://doi.org/10.1016/j.tetlet.2005.12.085