A six-step synthesis of (S)-5-ethenyl-3-(1-methyl-2-pyrrolidinyl)pyridine (SIB-1508Y) from (S)-nicotine

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Abstract

The anti-Parkinson's agent SIB-1508Y was prepared in six steps from (S)-nicotine in 20% overall yield. The strategy involves a regioselective formylation at C-5 of a 1,4-dihydronicotine intermediate. © 2005 Elsevier Ltd. All rights reserved.

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Comins, D. L., & Smith, E. D. (2006). A six-step synthesis of (S)-5-ethenyl-3-(1-methyl-2-pyrrolidinyl)pyridine (SIB-1508Y) from (S)-nicotine. Tetrahedron Letters, 47(9), 1449–1451. https://doi.org/10.1016/j.tetlet.2005.12.085

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