Snake venom toxins. The reactivity of the disulphide bonds of Naja nivea toxin α

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Abstract

The disulphide bonds of Naja nivea toxin α react stoichiometrically with dithioerythritol in the absence of denaturing agents. At an equimolar concentration of dithioerythritol to toxin, one disulphide is cleaved selectively. Alkylation leads to a derivative which retains toxicity and antigenicity. © 1974.

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Authors

  • Dawie P. Botes

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