A solitary cutaneous tumor with distinct areas of verruca and seborrheic keratosis-like lesion

  • Lazaris A
  • Paraskevakou H
  • Davaris P
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A single, exophytic, cutaneous tumor on the thigh of a 52-year-old man was examined by light microscopy, in situ hybridization and immunohistochemistry. It demonstrated distinct areas of verruca and of seborrheic keratosis-like morphology simultaneously. Focally, architectural abnormalities were noted in some deeper parts of the tumor, but there was no morphological evidence of malignancy. The patient has remained disease-free for two a half years after surgery. Biotinylated full genomic DNA probes of HPV confirmed the presence of types 6/11 exclusive in the verrucous portion of the neoplasm. In the verrucous component p53 protein was overexpressed and, additionally, increased Ki-67 immunopositive signals were detected, being localized below the HPV-DNA-expressing spinous cells.

Author-supplied keywords

  • HPV
  • In situ hybridization
  • Seborrheic keratosis
  • Skin

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