A single, exophytic, cutaneous tumor on the thigh of a 52-year-old man was examined by light microscopy, in situ hybridization and immunohistochemistry. It demonstrated distinct areas of verruca and of seborrheic keratosis-like morphology simultaneously. Focally, architectural abnormalities were noted in some deeper parts of the tumor, but there was no morphological evidence of malignancy. The patient has remained disease-free for two a half years after surgery. Biotinylated full genomic DNA probes of HPV confirmed the presence of types 6/11 exclusive in the verrucous portion of the neoplasm. In the verrucous component p53 protein was overexpressed and, additionally, increased Ki-67 immunopositive signals were detected, being localized below the HPV-DNA-expressing spinous cells.
Lazaris, A. C., Paraskevakou, H., & Davaris, P. S. (1999). A solitary cutaneous tumor with distinct areas of verruca and seborrheic keratosis-like lesion. Pathology and Oncology Research, 5(4), 320–323. https://doi.org/10.1053/paor.1999.0195