On the specificity and mechanism of action of m-tyrosine in antagonizing the central effects of reserpine in rats

  • Stoof J
  • Schipper J
  • Mulder A
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The interaction between m-tyrosine and reserpine was investigated. m-Tyrosine, when given in repeated doses shortly before and after the injection of reserpine, caused a partial but significant protection against the dopamine-depleting action of reserpine in the brain. Pretreatment with m-tyrosine also partially protected against the marked reductions in synaptosomal [3H]dopamine uptake and in release of [3H]dopamine from striatal slices prepared from rats pretreated with reserpine. However, 5-hydroxytryptophan and DOPA also appeared to have a protective action against reserpine, comparable with that of m-tyrosine. Therefore, the present data suggest that the interaction between m-tyrosine and reserpine. resulting in a protection of the dopamine stores against depletion, is not a specific effect. © 1976.

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  • J. C. Stoof

  • J. Schipper

  • A. H. Mulder

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