SPECT imaging of the benzodiazepine receptor in non-human primate brain with [123I]Ro 16-0154

  • Innis R
  • Zoghbi S
  • Johnson E
 et al. 
  • 5


    Mendeley users who have this article in their library.
  • 32


    Citations of this article.


We have used SPECT (single photon emission computed tomography) imaging in non-human primates to examine the time course and pharmacological specificity of123I-labeled Ro 16-0154 as an in vivo probe of the benzodiazepine receptor. Maximal brain uptake was reached approximately 70 min post i.v. administration of the radioligand and represented approximately 10% of the injected dose. The regional distribution of radioactive densities was consistent with the known distribution of benzodiazepine receptor in primate brain, with highest uptake localized over the occipital area. Washout of radioactivity was relatively slow with a rate of 3% per hour after the time of peak radioactivity. Injection of the benzodiazepine antagonist Ro 15-1788 (0.2-0.3 mg/kg i.v.) caused a rapid decrease of more than 90% of radioactivity from brain. In summary, [123I]Ro 16-0154 is a promising in vivo SPECT radioligand for the benzodiazepine receptor, with high brain uptake, a stable period of peak radioactivity, appropriate regional distribution, and ability to be displaced by other benzodiazepine receptor agents. © 1991.

Author-supplied keywords

  • Benzodiazepine receptors
  • Brain imaging
  • Single photon emission computed tomography (SPECT)

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Robert Innis

  • Sami Zoghbi

  • Eric Johnson

  • Scott Woods

  • Mohammed Al-Tikriti

  • Ronald Baldwin

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free