Stability and compatibility study of a carboplatin solution in syringes for continuous ambulatory infusion

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Abstract

The aim of this study was to verify the physico-chemical stability and compatibility between a 10 mg/ml carboplatin parenteral solution and the portable pump Intelliject® when stored at 25°C over an 8-day period. During this study, the pH was determined and carboplatin degradation products were assayed by a validated HPLC method. The compatibility study consisted of the titration of reducing substances, TLC of extracted additives, assay of extracted ions by AAS, resistivity measure, dynamometric test and UV, visible and IR absorption spectrophotometry. Stability and compatibility studies showed that a 10 mg/ml carboplatin parenteral solution remained chemically stable in the Intelliject® pump over a period of 8 days under the tested conditions.

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Valière, C., Arnaud, P., Caroff, E., Dauphin, J. F., Clément, G., & Brion, F. (1996). Stability and compatibility study of a carboplatin solution in syringes for continuous ambulatory infusion. International Journal of Pharmaceutics, 138(1), 125–128. https://doi.org/10.1016/0378-5173(96)04534-6

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