Stereocontrolled synthesis of all eight stereoisomers of the putative anti-androgen cyoctol

  • Mulzer J
  • Kaselow U
  • Graske K
 et al. 
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Abstract

All eight stereoisomers (1-4 and enantiomers) of the putative anti-androgen cyoctol have been synthesized along stereochemically unambiguous routes. The biological tests of all isomers indicated that cyoctol is not an anti-androgen, contrary to the patent literature. All eight stereoisomers of the putative anti-androgen cyoctol have been prepared and tested biologically. © 2004 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • 13-cis-Retinoic
  • Cyoctol
  • Putative anti-androgen cyoctol

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Authors

  • Johann Mulzer

  • Ulrich Kaselow

  • Klaus Dieter Graske

  • Holger Kühne

  • Andreas Sieg

  • Harry J. Martin

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