Stereoselective α-amidoalkylation of phenylglycinol-derived lactams. Synthesis of enantiopure 5,6-disubstituted 2-piperidones

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Abstract

The stereochemical outcome of α-amidoalkylation reactions of chiral nonracemic bicyclic lactams 2b and 2c with indole, allyltrimethylsilane, TMSCN and Grignard reagents to gain access to enantiopure 5,6-disubstituted 2-piperidones is discussed. © 2006 Elsevier Ltd. All rights reserved.

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Amat, M., Escolano, C., Gómez-Esqué, A., Lozano, O., Llor, N., Griera, R., … Bosch, J. (2006). Stereoselective α-amidoalkylation of phenylglycinol-derived lactams. Synthesis of enantiopure 5,6-disubstituted 2-piperidones. Tetrahedron Asymmetry, 17(10), 1581–1588. https://doi.org/10.1016/j.tetasy.2006.05.018

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