Stereoselective α-amidoalkylation of phenylglycinol-derived lactams. Synthesis of enantiopure 5,6-disubstituted 2-piperidones

  • Amat M
  • Escolano C
  • Gómez-Esqué A
 et al. 
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The stereochemical outcome of α-amidoalkylation reactions of chiral nonracemic bicyclic lactams 2b and 2c with indole, allyltrimethylsilane, TMSCN and Grignard reagents to gain access to enantiopure 5,6-disubstituted 2-piperidones is discussed. © 2006 Elsevier Ltd. All rights reserved.

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  • Mercedes Amat

  • Carmen Escolano

  • Arantxa Gómez-Esqué

  • Oscar Lozano

  • Núria Llor

  • Rosa Griera

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