Stereoselective synthesis of Sch 642305, an inhibitor of bacterial DNA primase

  • Ishigami K
  • Katsuta R
  • Watanabe H
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Abstract

Sch 642305 is a fungal nonanolide, which inhibits bacterial DNA primase and HIV-1 Tat transactivation. The enantioselective synthesis of Sch 642305 was succeeded starting from useful chiral building block via stereoselective dianion alkylation of β-ketosulfoxide and lactonization. © 2005 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • DNA primase
  • Lactonization
  • Sch 642305

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