An efficient and versatile method for the stereospecific construction of α,ω-cis- and α,ω-trans-disubstituted eight- and nine-membered cyclic ethers was developed. Cyclization of the hydroxy epoxides promoted by Eu(fod)3proceeded via an SN2 process and exo mode to provide the corresponding cyclic ethers in excellent yields. © 2003 Elsevier Science Ltd. All rights reserved.
Saitoh, T., Suzuki, T., Onodera, N., Sekiguchi, H., Hagiwara, H., & Hoshi, T. (2003). Stereospecific synthesis of eight- and nine-membered cyclic ethers by Eu(fod)3-mediated cyclization of hydroxy epoxides. Tetrahedron Letters, 44(13), 2709–2712. https://doi.org/10.1016/S0040-4039(03)00335-6