Stereospecific synthesis of eight- and nine-membered cyclic ethers by Eu(fod)3-mediated cyclization of hydroxy epoxides

  • Saitoh T
  • Suzuki T
  • Onodera N
 et al. 
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Abstract

An efficient and versatile method for the stereospecific construction of α,ω-cis- and α,ω-trans-disubstituted eight- and nine-membered cyclic ethers was developed. Cyclization of the hydroxy epoxides promoted by Eu(fod)3proceeded via an SN2 process and exo mode to provide the corresponding cyclic ethers in excellent yields. © 2003 Elsevier Science Ltd. All rights reserved.

Author-supplied keywords

  • Cyclization
  • Hydroxy epoxides
  • Oxocenes
  • Oxonenes
  • Regioselection

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Authors

  • Toshikazu Saitoh

  • Toshio Suzuki

  • Norihiro Onodera

  • Hideya Sekiguchi

  • Hisahiro Hagiwara

  • Takashi Hoshi

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