Strange-male-induced pregnancy disruption in mice: Potentiation by administration of 17β-estradiol to castrated males

  • Catanzaro D
  • Smith M
  • Muir C
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Abstract

Previous evidence suggests that androgen activity is necessary for strange males to disrupt early pregnancy in mice. Inseminated females were housed below castrated males, separated by a wire-mesh grid. Castrated males did not disrupt pregnancy, whereas those given daily injections of 27 or 81 μg of 17β-estradiol did so. In conjunction with previous evidence, these data suggest a similarity between the hormones involved in the capacity of males to disrupt pregnancy and the hormones directly implicated in the females' vulnerability to pregnancy disruption. © 1995.

Author-supplied keywords

  • 17β-Estradiol
  • Bruce effect
  • Estrogen
  • Implantation
  • Mice
  • Pregnancy disruption
  • Strange-male

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Authors

  • Denys de Catanzaro

  • Michael Smith

  • Cameron Muir

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