This article discusses a micro flow system that was constructed using the printed circuit board technique, and where fluid flow is by hydrostatic pressure. A new approach in the biosensor field, modulation of analyte concentration, is investigated. The flow and distribution of analyte molecules are examined by observing the dispersion of the analyte molecules under the condition of modulation of their concentration by alternate injection of analyte solution and pure water. A theoretical model for the description of a sequence of dye packages in a micro channel under laminar flow conditions is compared with the experimental data. © 2001 Elsevier Science B.V.
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